I would be very cautious about executing too many reactionary RD1 trades and remember that a score from RD 1 only remains in the price cycle for one round whereas for the remainder of the season, it will be two or three rounds.
Edwards-Helaire and Duvernay could quite easily fail to register two touchdowns again in RD2, fail to reach the end zone or exit due to injury. I would be focusing on areas such as target share for receivers or snap counts for running backs, with context, to further assist in decision making and waiting an extra round for more data, should be extremely beneficial.