My two cents.. spend as much time as you can on your starting squad. Trading is super important but it's hard to trade yourself back from a poor starting squad, and you ultimately end up with compromised premiums or just chasing the pack trying to get in the good players they started. Every year is different, but the general rule of thumb I follow is:
1. Get 3-4 top end premiums that can be VC/C players, and who I genuinely believe will be at worst, top 5 in their position. Ideally top 3 but that's not always easy. All things being equal, these players should be in your final completed team. Usually these will come from mid and ruck lines.
2. Rookies, where are the best ones? Ignore things like team balance and just get them in. There are usually some clear cut standouts so get them in, and then put in the "feel pretty good about" ones.
From here you can complete the team with rookies/premiums as money allows - don't worry about fancy strategies or anything yet. Just get the team completed.
Everyone will have a different view of the ideal starting squad, and it is very dependant on the year, so listen to the group talk here and get a gauge as to who might be the midpricers it's worth bending for, and who are the rookies/premiums you just have to have. If there is legit 5 standout defender rookies you might go light on premiums, or vice versa if the options aren't there you might go heavy. Don't get locked into one position (eg, I HAVE to have 2-3 premiums on each line) because ultimately, you start with X premiums and get to 22 premiums eventually.. and having the best rookies will get you there faster.
Couple of other thoughts:
1. Always leave room in your forwards for a mid player to get forward DPP. We got Bont, Parker etc last year, Macrae this year, and I'm going to confidently bet we'll get more next year. Other positions seem less common, but specifically forwards leave room.
2. If you are inclined to take a risk, take a popular risk. If it doesn't work out you aren't too far behind the majority, and if it does you get a nice edge. But if you are alone on your island with a pick that doesn't work, it's rough.
3. The first few rounds should be for correction trades - $700k mid premium has scored back to back 80's? A player you liked doesn't have the role you expected? You missed a rookie that looks fantastic? Get them in! Starting team is important, but almost more important is your round 3 team. That's the one that should be the best it can be based on the information you now have.
4. If you are torn between various opinions, back the one you think. It feels better to back yourself and be wrong than to not back yourself and watch that pick dominate.
5. Injury history is real. Players sometimes shake it for a season or two, but if a guy has a history, he has a history. Doesn't mean don't pick them, but you almost have to assign a correction trade to them. So don't pick a stack of them in your team or you're just putting an anchor around your neck.
6. PODs are great but don't focus on a POD for the sake of it. Early in the season, there is safety in numbers, and rookie roulette/Captain loopholes will separate the pack over time. If there is a good POD grab them, but POD hunting early usually backfires.
7. Don't have a baby 2 weeks before the seasons starts (joking but that did massively derail my year as I've had to come from a LONG way back!).
Wrote these after a 4very interrupted night of sleep so if they don't make sense, no hate!