Liverpool manager Jurgen Klopp has confirmed that Naby Keita is available but fellow midfielders Fabinho and Thiago remain out.
James Milner will also definitely miss out with a thigh injury sustained against Manchester United.
Dele Alli and Harry Winks may return after missing out against Burnley but Ryan Sessegnon remains out.
Manchester United are boosted by the news that both Raphael Varane and Anthony Martial have returned to training and are available.
Paul Pogba is ruled out as he begins a three-match ban.
Chelsea are strengthened by the return to fitness of Cesar Azpilicueta, N'Golo Kante and Ruben Loftus-Cheek.
Andreas Christensen is also available after dental surgery but Mateo Kovacic is out with a hamstring problem.
Forwards Timo Werner and Romelu Lukaku remain sidelined with respective hamstring and ankle injuries.
Raheem Sterling returned from a back problem to play in the EFL Cup on Wednesday, but Ferran Torres is a long-term absentee.
Crystal Palace forward Wilfried Zaha made his comeback from illness as a substitute against Newcastle last week.
The Eagles remain without Eberechi Eze and Nathan Ferguson.
Norwich City midfielder Billy Gilmour is expected to return to the starting line-up after he was ineligible to face parent club Chelsea last weekend.
Przemyslaw Placheta and Todd Cantwell could both make their comeback but Ben Gibson is suspended.
Leeds United midfielder Raphinha has overcome the ankle injury that forced him off against Wolves.
Junior Firpo should feature following a muscle strain but Patrick Bamford and Luke Ayling remain out.
Goalkeeper Emiliano Martinez, who had travelled to Argentina during the week for family reasons, is available for Aston Villa.
Morgan Sanson and Jaden Philogene-Bidace are sidelined by illness but Leon Bailey could make his first start.