Armando Broja is available following a brief spell out with an ankle problem.
Aston Villa remain without injured former Saints striker Danny Ings, Bertrand Traore and Douglas Luiz.
Ezri Konsa is banned, meaning a likely recall for Tyrone Mings, but Jacob Ramsey has overcome an ankle sprain and Morgan Sanson and Jaden Philogene-Bidace are available after illness.
Raphael Varane will be out for a month.
Victor Lindelof has a minor injury and will be monitored, while Paul Pogba is serving a three-match ban.
Manchester City centre-back Aymeric Laporte is suspended following his red card against Crystal Palace.
His absence is likely to mean John Stones starts.
City may need to assess full-back Kyle Walker, who was substituted against Club Bruges on Wednesday after suffering what manager Pep Guardiola called "a kick on his foot".
Bryan Mbeumo, who was an unused substitute last weekend because of a hamstring issue, should be fit to start.
Kristoffer Ajer faces at least six weeks out with a similar injury, while Yoane Wissa and Shandon Baptiste are still sidelined.
Norwich City defender Ben Gibson is available after serving a one-match ban.
Todd Cantwell, Sam Byram and Christoph Zimmermann all remain injured.
Chelsea are monitoring the fitness of midfielder Mason Mount, who has missed successive games because of illness.
Romelu Lukaku, Timo Werner and Mateo Kovacic are sidelined but Christian Pulisic could play after making his return from an ankle injury as a Champions League substitute in midweek.
Burnley winger Aaron Lennon has been ill and will be assessed ahead of the trip to Stamford Bridge.
Long-term absentee Dale Stephens remains out with an ankle injury.
Crystal Palace midfielder Eberechi Eze played for the development side in midweek and is closing in on a return from a long-term Achilles injury.
Full-back Nathan Ferguson remains sidelined with a similar problem.
Wolves defender Fernando Marcal could return after an ankle injury.
Willy Boly, who is yet to play in the Premier League this season, is pushing for some time on the pitch after being an unused substitute against Everton on Monday.
Brighton will assess the fitness of defender Dan Burn, who missed the draw at Anfield with a knee problem.
Aaron Connolly could be fit after a minor heel injury but Danny Welbeck and Steven Alzate are long-term absentees.
Newcastle United's interim head coach Graeme Jones is without the services of goalkeeper Freddie Woodman because of a muscle injury.
Defender Paul Dummett also misses out, but is nearing a return from his calf problem.
Sunday games to follow...