Round 12 looks to be the hardest of the BYE rounds. Here's a breakdown of all the significant players that will be out in each round off the top of my head:
Round 11: Adelaide, Brisbane, Carlton, Hawks, Richmond, Dogs
Significant Zeros: Dangerfield, Sloane, Jacobs, Rockliff, Beams, Hanley, Zorko, Rich, Leuenberger, Murphy, Simpson, Gibbs, Walker, Kruezer, Lewis, Roughead, Mitchell, Rioli, Cotchin, Martin, Deledio, Ellis, Liberatore
Round 12: Pies, Essendon, Freo, Gold Coast, Saints, Swans.
Significant Zeros: Pendlebury, Sidebottom, Swan, Watson, Heppell, Hibberd, Goddard, Fyfe, Mundy, Barlow, Sandilands, Ablett, Bennell, Malceski, Nick Riewoldt, Jack Steven, Franklin, Parker, McVeigh, JPK, Jack
Round 13: Cats, North, Western Sydney, Melbourne, Port, West Coast
Significant Zeros: Selwood, Johnson, Bartel, Dal Santo, Goldstein, Ward, Griffen, Mumford, Treloar, Greene, Jones, Gray, Boak, Wines, Wingard, Ryder, Priddis, Nic Nat